Metabolic Syndrome and Risk of Colorectal Adenoma Development

Two Asian-Pacific Epidemiologic Studies showed an increased risk of colorectal adenoma
development associated with MeS: (1) the Self-Defense Forces Health Study, carried
out between 1995 and 2002 at two Self Defense Forces hospitals in Japan [44] and
(2) one study carried out at the Center for Health Promotion, Samsung Medical Center,
Seoul, Korea, between March 2004 and December 2005 [45]. Both studies included
subjects who underwent colonoscopy as a s creening examination for polyps. Apart
from the association of MeS with colorectal adenoma, an increased risk for MeS was
more evident for proximal than distal colon, for multiple (3), and for advanced adenoma.
Abdominal obesity of the individual components of MeS was an important risk
factor for colorectal adenoma. Thus, the MeS appears to be a crucial entity with regard
to the prevention of colorectal adenoma and consequently colorectal cancer.